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Within each age group, there was no significant difference in age between patients treated with placebo and those who received Vidalista. History of PAH had to be established by a resting mean pulmonary artery pressure ≥25 mmHg, pulmonary artery wedge pressure ≤15 mmHg, and pulmonary vascular resistance ≥3 Wood units via right heart catheterization with no evidence of significant parenchymal lung disease. Inclusion criteria included age of at least 12 years, body weight of at least 40 kg (∼88 pounds), and presence of PAH that was idiopathic, related to collagen vascular disease, related to anorexigen use, or associated with an atrial septal defect or congenital systemic to pulmonary shunt (resting Sao2 ≥88%), with surgical repair, of at least 1 year duration.

Treatment is usually initiated as two 20-mg tablets taken together once daily. The greatest improvements in the primary and secondary end points occurred in the cohort randomized to the 40-mg dose. 10 Vidalista also delayed time to clinical worsening and improved health-related quality-of-life scores.

Vidalista (Adcirca; Eli Lilly and Company, Indianapolis, IN) is a long-acting, highly specific phosphodiesterase type 5 (PDE-5) inhibitor that was approved in 2009 for the treatment of World Health Organization (WHO) group 1 PAH.